Gwas in autoimmune disease
WebApr 1, 2024 · Here, we combined text mining with a systematic review and formed a catalog of 85 studies with evidence of fine mapping for at least one autoimmune GWAS locus. … WebApr 12, 2024 · GWAS summary data of a total of 17 independent studies related to allergic diseases were collected from the IEU GWAS database for the outcome dataset. Significant causal relationships were obtained between gut microbiome features including Ruminococcaceae , Eggerthella , Bifidobacterium , Faecalibacterium , and Bacteroides …
Gwas in autoimmune disease
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WebFor more than a decade, genome-wide association studies have been applied to autoimmune diseases and have expanded our understanding on the pathogeneses. Genetic risk factors associated with diseases and … WebApr 11, 2024 · GWAS summary statistics for the 7 autoimmune disease and WBC counts are publicly available in the GWAS catalog. The list of SNPs that were included in the genetic instruments for RA, SLE, and MS ...
WebJan 18, 2024 · We then systematically review the applications of statistical fine-mapping in autoimmune disease studies to highlight the value of statistical fine-mapping in biological contexts. Genome-wide association studies (GWAS) have identified thousands of loci in the human genome that are associated with different traits such as height, body mass index ... WebJan 24, 2024 · Myasthenia gravis is a chronic autoimmune disease characterized by autoantibody-mediated interference of signal transmission across the neuromuscular junction. ... The autoimmune summary statistics downloaded from the GWAS catalog were Crohn’s disease: GCST004132, rheumatoid arthritis: GCST002318, systemic lupus …
WebAug 3, 2024 · The autoimmune disease-susceptible SNPs identified in GWAS are frequently located in non-coding regions, as well as coding regions. Notably, many SNPs are located in SEs. Meanwhile, eRNAs regulate SE activity and are also associated with autoimmune diseases. WebMore than 30 common variant JIA loci have been identified in genome‐wide association studies (GWAS); however, the number of JIA loci is far less than that of other …
WebFeb 5, 2024 · Epidemiological and clinical studies have suggested comorbidity between amyotrophic lateral sclerosis (ALS) and autoimmune disorders. However, little is known about their shared genetic architecture. To examine the relation between ALS and 10 autoimmune diseases, including asthma, celiac disease (CeD), Crohn’s disease (CD), …
WebGenome-Wide Association Studies. Medical » Human Genome. Rate it: GWAS. Game Was A Success. Computing » Gaming. Rate it: mmd thomas bowlrollWebThe main purpose of this Special Issue is to provide up-to-date information on the most important topics related to the genetics of various systemic and organ-specific … mmd thomson reutersWebObjectives Autoimmune and allergic diseases are outcomes of the dysregulation of the immune system. Our study aimed to elucidate differences or shared components in genetic backgrounds between … mmd thomas downloadWebNov 25, 2024 · Background Genome-wide association studies (GWAS) have identified pervasive sharing of genetic architectures across multiple immune-mediated diseases (IMD). By learning the genetic basis of IMD risk from common diseases, this sharing can be exploited to enable analysis of less frequent IMD where, due to limited sample size, … mmd threejsWebJun 18, 2024 · None of these variants reached a nominal significance in our pernicious anemia GWAS meta-analysis, confirming that the observed associations are not mainly driven by concomitant autoimmune disease ... initialization\\u0027s cwWebApr 19, 2024 · Beyond GWAS: Understanding Etiologic Heterogeneity (Minisymposium) ... Immune Factors, and Metabolomics: The Immunogenetic Basis of Hepatitis B Virus-related Hepatocellular Carcinoma: ... of deep learning approaches applied to hematoxylin and eosin-stained whole slide images from women with benign breast disease to predict risk … initialization\u0027s eaWebMore than 30 common variant JIA loci have been identified in genome‐wide association studies (GWAS); however, the number of JIA loci is far less than that of other autoimmune diseases. To date, GWAS on JIA have been formally performed in seronegative JIA and systemic JIA , while other studies show that the loci implicated in seropositive ... mmd throne