WebMay 1, 2016 · We present an operationally simple approach to 2,2'-bipyridine macrocycles. Our method uses simple starting materials to produce these previously hard to access rotaxane precursors in remarkable yields (typically >65%) across a range of scales (0.1-5 mmol). All of the macrocycles reported are eff … WebStephen Goldup’s group at the University of Southampton in the UK is well known for making mechanically-interlocked molecules, particularly rotaxanes. However, the challenge of making these molecules isn’t enough for Goldup. He is developing faster and higher yielding synthetic methods to evolve these chemical curios into molecules that ...
Did you know?
WebFeb 13, 2008 · Mónica Alvarez-Pérez 1 , Stephen M Goldup, David A Leigh, Alexandra M Z Slawin. Affiliation 1 School of Chemistry, University of Edinburgh, The King's Buildings, West Mains Road, Edinburgh, EH9 3JJ, UK. PMID: 18201092 DOI: 10.1021/ja7102394 No abstract available ... WebResearch in the Goldup Group focusses on developing new synthetic methods to make mechanically interlocked molecules, particulary mechanically chiral molecules, and their …
WebJan 11, 2013 · Here, we report on the design, synthesis, and operation of an artificial small-molecule machine that travels along a molecular strand, picking up amino acids that block its path, to synthesize a peptide in a sequence-specific manner. The chemical structure is based on a rotaxane, a molecular ring threaded onto a molecular axle. WebJun 13, 2024 · Introduction. Chiral molecules occupy a special place in synthetic chemistry because of their ubiquity in biological systems and emerging applications in materials science. 1 A tetrahedral carbon atom bearing four different substituents is the archetypal unit that can give rise to molecular chirality. 2, 3, 4 However, chirality in organic molecules …
WebMay 25, 2014 · 1 School of Biological and Chemical Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK. [email protected]. PMID: 24434901 DOI: 10.1039/c3cc47842d Abstract Research on mechanically interlocked molecules has advanced substantially over the last five decades. A large proportion of the published … WebEdgbaston. Birmingham. B15 2TT. UK. Steve is Professor of Chemistry at the University of Birmingham, having previously held positions at the University of Southampton, Queen Mary University of London and the University of Edinburgh. Research in the Goldup Group focusses on developing new synthetic methods to make mechanically interlocked ...
WebSM Goldup, DA Leigh, RT McBurney, PR McGonigal, A Plant. Chemical Science 1 (3), 383-386, 2010. 124: 2010: A three-compartment chemically-driven molecular information ratchet. A Carlone, SM Goldup, N Lebrasseur, DA Leigh, A Wilson. Journal of the American Chemical Society 134 (20), 8321-8323, 2012. 112:
WebActive metal template synthesis is a powerful new strategy for the construction of rotaxanes, catenanes and other mechanically interlocked molecular structures. The key feature is … cheap dnp online programshttp://blavatnikawards.org/honorees/profile/stephen-goldup/ cheap dnp programs onlineWebAug 9, 2024 · Neal, E. A. & Goldup, S. M. Competitive formation of homocircuit [3]rotaxanes in synthetically useful yields in the bipyridine-mediated active template CuAAC reaction. … cutting practice preschoolWebSep 21, 2015 · A rotaxane‐based Au catalyst was developed and the effect of the mechanical bond on its behavior was studied. Unlike the non‐interlocked thread, the rotaxane requires a catalytically innocent cofactor, the identity of which significantly influences both the yield and diastereoselectivity of the reaction. cutting practice preschool free printableWebApr 4, 2024 · The high selectivity of the reactions to produce catenanes 3 suggested that the AT-CuAAC reaction would be suitable for a multicomponent cyclization approach to catenanes from small, simple starting materials by a controlled oligomerization pathway, a significant benefit for the production of interlocked molecules on larger scales. To this … cheap dnsWebTying the knot: The marriage of catalysis and coordination chemistry enables two Cu I ions (red; see picture) to work in partnership for the synthesis of a molecular trefoil knot. One ion entangles an acyclic building block to create a loop in the ligand, and the other gathers the ligand's reactive end-groups, threads the loop, and catalyzes the covalent capture of … cheap dns registrationWebJan 11, 2013 · The chemical structure is based on a rotaxane, a molecular ring threaded onto a molecular axle. The ring carries a thiolate group that iteratively removes amino … cheap dna tests for dogs